Science

Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing

Published 2 weeks ago iNFO Vi2w ago

Submission history

Received: January 24, 2024

Accepted: August 1, 2024

Published online: September 3, 2024

Published in issue: September 10, 2024

Acknowledgments

We are grateful to Dr. Robert B. Darnell, Dr. Manabu Abe, Dr. Atsushi Nakanishi, and all members of the laboratories. We would like to thank the following funding agencies for the support: The 2nd Shonan incubation laboratories (SIL) Research Fund, Takeda Pharmaceutical Company, Ltd., Japan, and Grant-in-Aid for Scientific Research, Japan Society for the Promotion of Science (JSPS). JP20H00485a (H.O. and M. Yano), Grant-in-Aid for Transformative Research Areas(A), Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT), JP22H05589, Grant-in-Aid for Scientific Research, JSPS, JP19H03543, SERIKA Fund, The Naito Foundation, The NOVARTIS Foundation and Japan Agency for Medical Research and Development (AMED)-CREST (JP23gm1710010) (M. Yano), Grant-in-Aid for Scientific Research, JSPS, JP19K07345, and JP22K06879, The Sumitomo Foundation, The General Insurance Association of Japan and ALS Foundation, Japan ALS Association (Y.H.-Y.) and The Takeda Science Foundation, Japan (Y.H.-Y. and M. Yano).

Author Contributions

Y.H.-Y., H.O., and M. Yano designed research; Y.H.-Y., T.F., T.M., and M. Yano performed research; Y.H.-Y, K.O., H.T., and M. Yano contributed new reagents/analytic tools; Y.H.-Y., T.F., T.M., T.O., M.N., K.Y., M. Yugami, M.S., C.N., K.S., A.K., O.O., H.O., and M. Yano analyzed data; and Y.H.-Y. and M. Yano wrote the paper.

Competing Interests

H.O. is a paid member of the Scientific Advisory Boards of San Bio Co., Ltd., and K Pharma Inc. M. Yano is a paid member of the Scientific Advisory Board of K Pharma Inc.